Objective To study the value of endoscope-assisted application in prosthetic augmentation mammoplasty. Methods A total of 100 patients who underwent prosthetic augmentation mammoplasty in Huizhou Yahan Medical Aesthetic Clinic from January 2023 to December 2024 were selected as the research subjects. According to different surgical methods, they were divided into the control group and the observation group, with 50 patients in each group. The control group received traditional augmentation mammoplasty, and the observation group received endoscope-assisted augmentation mammoplasty. The breast plastic effect, stress level, surgical indexes, recovery situation and complications were compared between the two groups. Results The excellent and good rate of breast plastic surgery in the observation group was 98.00%, which was higher than 84.00% in the control group (P <0.05). After operation, the levels of CRP, NE and E in the observation group were lower than those in the control group (P <0.05). The intraoperative blood loss, incision length and operation time in the observation group were all better than those in the control group (P <0.05). The time for incision healing and indwelling catheter in the observation group were all shorter than those in the control group (P <0.05). The incidence of complications in the observation group was 2.00%, which was lower than 14.00% in the control group (P <0.05). Conclusion The application value of endoscope-assisted in prosthetic augmentation mammoplasty is definite. It can not only reduce the surgical stress but also reduce the trauma and bleeding, effectively prevent the incidence of complications, improve the effect of breast plastic surgery, and is beneficial to improving the postoperative recovery speed, which is worthy of clinical application.