Objective To explore the application effect and safety of autologous abdominal dermis filling for the repair of nasal base depression. Methods A total of 96 patients with nasal base depression who underwent repair treatment in Gonice Medical Aesthetic Hospital from March 2022 to October 2024 were selected as the research subjects. According to the principle of random envelope lottery, they were divided into the control group and the study group, with 48 patients in each group. The control group received filling and repair treatment with particulated costal cartilage, and the study group received filling and repair treatment with autologous abdominal dermis. The changes in nasofacial angle and nasofrontal angle, complications and clinical efficacy were compared between the two groups. Results The nasofacial angle and nasofrontal angle in the study group after surgery were higher than those in the control group, and the differences were statistically significant (P <0.05). The incidence of complications in the study group was 4.17%, which was lower than 20.83% in the control group, and the difference was statistically significant (P <0.05). The excellent and good rate of treatment in the study group was 97.92%, which was higher than 83.33% in the control group, and the difference was statistically significant (P <0.05). Conclusion Autologous abdominal dermis filling for the repair of nasal base depression can improve the aesthetic degree of patients, reduce the incidence of complications, and enhance the clinical efficacy.