Objective To study the effect of 755 nm picosecond laser device combined with rhEGF on enlarged pores improvement in patients with relaxed enlarged pores. Methods A total of 83 patients with relaxed enlarged pores admitted to our hospital from January to July 2023 were selected as the research subjects. According to the random number table method, they were divided into the control group (42 patients) and the study group (41 patients). The control group was treated with 755 nm picosecond laser device, and the study group was treated with 755 nm picosecond laser device combined with rhEGF. The clinical efficacy, enlarged pores improvement score, pores number, adverse reactions and treatment satisfaction were compared between the two groups. Results The total effective rate of treatment in the study group (95.12% ) was higher than that in the control group (76.19%), and the difference was statistically significant (P <0.05). There was no significant difference in the score of enlarged pores improvement between the two groups after the 1st, 2nd, 3rd, and 4th treatments (P >0.05), and the score of enlarged pores improvement in the study group after the 5th treatment was lower than that in the control group, and the difference was statistically significant (P <0.05). The number of pores in the two groups after treatment was less than that before treatment, and that in the study group was less than that in the control group (P <0.05). The incidence of adverse reactions in the study group (4.88%) was lower than that in the control group (23.81%) , and the difference was statistically significant (P <0.05). The treatment satisfaction rate in the study group (97.56%) was higher than that in the control group (85.71%), and the difference was statistically significant (P <0.05). Conclusion 755 nm picosecond laser+rhEGF in the treatment of relaxed enlarged pores can achieve an ideal treatment effect, reduce the incidence of adverse reactions, improve the visibility and enlargement of pores, and enhance the treatment satisfaction.