Objective To analyze the effect of supramolecular salicylic acid chemical peeling combined with gold radiofrequency microneedle on skin physiological function in patients with enlarged pores. Methods A total of 82 patients with enlarged pores admitted to Xi'an Yestar Medical Beauty Hospital from December 2023 to December 2024 were selected as the research subjects. According to different treatment plans, they were divided into the reference group and the experimental group, with 41 patients in each group. The reference group was treated with gold radiofrequency microneedle, and the experimental group was treated with supramolecular salicylic acid chemical peeling combined with gold radiofrequency microneedle. The skin physiological function,facial appearance satisfaction, pore count and complications were compared between the two groups. Results After treatment, the moisture score in the experimental group was higher than that in the reference group, and the scores of sebum and transepidermal water loss in the experimental group were lower than those in the reference group (P <0.05). After treatment, the Face-Q score in the experimental group was higher than that in the reference group (P <0.05). After treatment, the pore count in the experimental group was lower than that in the reference group (P <0.05). There was no significant difference in the incidence of complications between the two groups (P >0.05). Conclusion Supramolecular salicylic acid chemical peeling combined with gold radiofrequency microneedle has shown good efficacy in the treatmant of enlarged pores. It can effectively improve the skin physiological function of patients, and is conducive to improving patients' satisfaction with their facial appearance, with a lower incidence of complications after treatment and higher application safety.