光动力疗法联合消痤膏与光动力疗法治疗中重度痤疮的临床研究
作者:
作者简介:

刘迪辉(1992.11-),女,湖南娄底人,硕士,主治医师,主要从事光动力及激光美容方向工作

通讯作者:

姚明珠(1983.12-),女,广东梅州人,硕士,主任医师,主要从事光动力及激光美容方向工作

中图分类号:

R758.73+3

基金项目:

广州地区中西医协同临床重大创新技术项目( 编号:穗卫函〔2023〕2318号)


Effect of Photodynamic Therapy Combined with Xiaocuo Ointment on Skin Barrier Function in Patients with Moderate to Severe Acne
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    摘要:

    目的 探讨光动力疗法联合消痤膏治疗中重度痤疮(MSA)的临床效果及对患者皮肤屏障功能 的影响。方法 选取2020年10月-2024年8月我院诊治的60例MSA患者为研究对象,采用随机数字表法分为 对照组(n =30)和观察组(n =30)。对照组采取光动力疗法,观察组实施光动力疗法联合消痤膏治疗, 比较两组临床疗效、皮肤屏障功能、皮损情况、不良反应发生率。结果 观察组治疗总有效率为90.00%, 高于对照组的66.67%(P <0.05);观察组治疗后SCH高于对照组,TEWL、pH值、皮肤油脂含量均低 于对照组(P <0.05);两组治疗后1、2、3周及3个月的皮损积分均低于治疗前,且观察组低于对照组 (P <0.05);两组不良反应发生率比较,差异无统计学意义(P >0.05)。结论 光动力疗法联合消痤治疗 MSA的临床效果较好,能够改善皮损情况及皮肤屏障功能,且不会增加不良反应的发生。

    Abstract:

    Objective To explore the clinical effect of photodynamic therapy combined with Xiaocuo ointment in the treatment of moderate to severe acne (MSA) and its influence on the skin barrier function. Methods A total of 60 patients with MSA who were diagnosed and treated in our hospital from October 2020 to August 2024 were selected as the research subjects. According to the random number table method, they were divided into the control group (n =30) and the observation group (n =30). The control group received photodynamic therapy, and the observation group received photodynamic therapy combined with Xiaocuo ointment. The clinical effect, skin barrier function, skin lesion and adverse reaction rate were compared between the two groups. Results The total treatment effective rate in the observation group (90.00%) was higher than that in the control group (66.67%) (P <0.05). After treatment, the SCH in the observation group was higher than that in the control group, and the TEWL, pH value and skin oil content in the observation group were all lower than those in the control group (P <0.05). The skin lesion scores in the two groups at 1 week, 2 weeks, 3 weeks and 3 months after treatment were lower than those before treatment, and the scores in the observation group were lower than those in the control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P >0.05). Conclusion Photodynamic therapy combined with Xiaocuo ointment has a good clinical effect in the treatment of MSA, which can improve the skin lesion symptoms and skin barrier function without increasing adverse reactions.

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刘迪辉,姚明珠,程必红,等.光动力疗法联合消痤膏与光动力疗法治疗中重度痤疮的临床研究[J].医学美学美容,2025,34(8):9-12.

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  • 在线发布日期: 2025-05-26