卡铂三醇软膏联合卤米松乳膏治疗寻常型银屑病的效果
作者:
作者简介:

弋渊凡(1988.5-),男,陕西西安人,本科,主管药师,主要从事药学相关工作

通讯作者:

张乐(1992.2-),女,陕西西安人,本科,主管药师,主要从事药学相关工作

中图分类号:

R758.63


Effect of Calcipotriol Ointment Combined with Halometasone Cream in the Treatment of Psoriasis Vulgaris
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    摘要:

    的 探讨卡泊三醇软膏联合卤米松乳膏治疗寻常型银屑病的效果。方法 选取2022年 1月-2023年3月我院收治的80例寻常型银屑病患者为研究对象,随机分为观察组与对照组,各40例。 对照组予以卤米松乳膏治疗,观察组予以卡泊三醇软膏联合卤米松乳膏治疗,比较两组临床症状缓 和时间、炎性因子水平、皮损程度、瘙痒程度及不良反应发生情况。结果 观察组皮损、红斑丘疹、 瘙痒、鳞皮屑缓和时间均低于对照组,差异有统计学意义(P<0.05);观察组治疗后TNF-α、IL-17 以及IL-6水平均低于对照组,差异有统计学意义(P<0.05);观察组治疗后PASI、VAS评分均低于对照 组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 予以寻常型银屑病患者卡泊三醇软膏联合卤米松乳膏治疗,降低炎性因子水平,缩短临床症状改善时 间,改善皮损、瘙痒状况,安全性较高,值得临床应用。

    Abstract:

    Objective To investigate the effect of calcipotriol ointment combined with halometasone cream in the treatment of psoriasis vulgaris. Methods A total of 80 patients with psoriasis vulgaris admitted to our hospital from January 2022 to March 2023 were randomly divided into observation group and control group, with 40 patients in each group. The control group was treated with halometasone cream, and the observation group was treated with calcipotriol ointment combined with halometasone cream. The clinical symptom relief time, inflammatory factor level, skin lesion degree, pruritus degree and adverse reactions were compared between the two groups. Results The remission time of skin lesions, erythema papules, itching and scales in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05). After treatment, the levels of TNF-α, IL-17 and IL-6 in the observation group were lower than those in the control group, the differences were statistically significant (P<0.05).After treatment, the PASI and VAS scores of the observation group were lower than those of the control group, and the differences were statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Calcipotriol ointment combined with halometasone cream in patients with psoriasis vulgaris can reduce the level of inflammatory factors, shorten the improvement time of clinical symptoms, improve skin lesions and itching, with high safety, which is worthy of clinical application.

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弋渊凡,张 乐.卡铂三醇软膏联合卤米松乳膏治疗寻常型银屑病的效果[J].医学美学美容,2023,32(19):59-62.

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  • 在线发布日期: 2023-11-08