萘替芬酮康唑乳膏治疗马拉色菌毛囊炎的临床效果
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李学富(1984.6-),女,广西来宾人,本科,主治医师,主要从事皮肤性病学相关研究

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R753.3


Clinical effect of Naftifine Hydrochloride and ketoconazole Cream in the Treatment of Malassezia Folliculitis
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    摘要:

    目的 研究萘替芬酮康唑乳膏治疗马拉色菌毛囊炎的临床效果。方法 选择来宾市人民医院 2020年4月-2021年12月收治的50例马拉色菌毛囊炎患者,按照随机数字表法分为对照组和观察组,各 25例。对照组采用2%硝酸咪康唑乳膏进行治疗,观察组采用萘替芬酮康唑乳膏进行治疗,比较两组临 床疗效、真菌清除率、生活质量及不良反应发生情况。结果 观察组治疗总有效率为96.00%,高于对照 组的76.00%(P<0.05);观察组真菌清除率为92.00%,高于对照组的68.00%(P<0.05);观察组 精神健康、社会功能、一般健康、生理职能、精力、躯体功能、情感功能、生理功能评分均高于对 照组(P<0.05);观察组不良反应发生率为8.00%,略低于对照组的12.00%,但差异无统计学意义(P >0.05)。结论 应用萘替芬酮康唑乳膏对马拉色菌毛囊炎患者进行治疗,可有效提升临床疗效以及真菌清 除率,改善患者生活质量,且不增加不良反应。

    Abstract:

    Objective To study the clinical efficacy of naftifine hydrochloride and ketoconazole cream in the treatment of Malassezia folliculitis. Methods Fifty patients with Malassezia folliculitis admitted to the People's Hospital of Laibin from April 2020 to December 2021 were selected and divided into control group and observation group according to the random number table method, with 25 patients in each group. The control group was treated with 2% miconazole nitrate cream, and the observation group was treated with naftifine hydrochloride and ketoconazole cream. The clinical efficacy, fungal clearance rate, quality of life and adverse reactions were compared between the two groups. Results The total effective rate of treatment in the observation group was 96.00%, which was higher than 76.00% in the control group (P<0.05). The fungal clearance rate of the observation group was 92.00%, which was higher than 68.00% of the control group (P<0.05). The scores of mental health, social function, general health, physiological function, energy, physical function, emotional function and physiological function in the observation group were higher than those in the control group (P<0.05). The incidence of adverse reactions in the observation group was 8.00%, which was slightly lower than 12.00% in the control group, but the difference was not statistically significant (P>0.05). Conclusion The application of naftifine hydrochloride and ketoconazole cream in the treatment of patients with Malassezia folliculitis can effectively improve the clinical efficacy and fungal clearance rate, improve the quality of life, and do not increase adverse reactions.

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李学富.萘替芬酮康唑乳膏治疗马拉色菌毛囊炎的临床效果[J].医学美学美容,2023,32(11):92-95.

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  • 收稿日期:2023-04-23
  • 在线发布日期: 2023-08-02