王婷婷（1987.5-），女，四川宜宾人，本科，主治医师，主要从事整形美容相关手术及治疗工作
R765.4+1
目的 探讨激光透皮下氨甲环酸给药联合甘草酸苷治疗黄褐斑的疗效。方法 选取我院整形美容 科2021年12月-2022年11月收治的90例黄褐斑患者为研究对象，采用随机数字表法分为试验A组、试验 B组和对照组，每组30例。对照组给予外用3%氨甲环酸精华给药联合口服复方甘草酸苷片，试验A组在 对照组治疗基础上给予Q开关Nd：YAG激光辅助外用3%氨甲环酸精华，试验B组在对照组治疗基础上给 予点阵激光辅助透皮下外用3%氨甲环酸精华，比较三组临床疗效、黄褐斑面积及严重程度（MASI）评 分、治疗满意度、皮肤色斑变化率及不良反应发生情况。结果 试验A组治疗总有效率高于对照组、试验B 组（P ＜0.05）；试验A组MASI评分低于对照组、试验B组（P ＜0.05）；试验A组皮肤色斑变化率高于对照 组、试验B组（P ＜0.05）；试验A组治疗满意度高于对照组、试验B组（P ＜0.05）；三组治疗期间均未出 现明显不良反应。结论 Q开关Nd：YAG激光辅助外用3%氨甲环酸精华给药联合甘草酸苷口服治疗黄褐斑 的疗效确切，可有效缩小黄褐斑面积，减轻病情严重程度，色素沉着几率小，患者对治疗效果的满意度较 高，也无明显不良反应，安全性较高。
Objective To explore the efficacy of laser transdermal administration of tranexamic acid combined with glycyrrhetinic acid glycoside in the treatment of chloasma. Methods A total of 90 patients with chloasma admitted to the plastic surgery and beauty department of our hospital from December 2021 to November 2022 were selected as the research objects. They were divided into experimental group A, experimental group B and control group by random number table method, with 30 cases in each group. The control group was given topical 3% tranexamic acid essence combined with oral compound glycyrrhizin tablets. The experimental group A was given Q-switched Nd:YAG laser-assisted topical 3% tranexamic acid essence on the basis of the control group. The experimental group B was given lattice laser-assisted subcutaneous topical 3% tranexamic acid essence on the basis of the control group. The clinical efficacy, melasma area and severity index (MASI) score, treatment satisfaction, skin stain change rate and adverse reactions were compared among the three groups. Results The total effective rate of treatment in the experimental group A was higher than that in the control group and the experimental group B (P <0.05). The MASI score of group A was lower than that of control group and group B (P <0.05). The change rate of skin color spot in group A was higher than that in control group and group B (P <0.05). The treatment satisfaction of experimental group A was higher than that of control group and experimental group B (P <0.05). No obvious adverse reactions occurred during the treatment of the three groups. Conclusion Q-switching Nd:YAG laser assisted topical administration of 3% tranexamic acid essence combined with oral glycyrrhizin is effective in the treatment of chloasma, which can effectively reduce the area of chloasma, reduce the severity of the disease, and the probability of pigmentation is small. Meanwhile, the patient's satisfaction with the treatment effect is high, there are no obvious adverse reactions, and the safety is high.
王婷婷,夏琼平,马玲玲,等.激光透皮下氨甲环酸给药联合甘草酸苷在黄褐斑中的应用[J].医学美学美容,2023,32(9):40-43.
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