Objective To explore the application effect of radiofrequency technology in facial rejuvenation treatment. Methods A total of 70 patients who underwent facial rejuvenation treatment in the Second People's Hospital of Hami from February to August 2022 were selected as the research objects. They were divided into control group and experimental group by random number table method, with 35 patients in each group. The control group was treated with water light injection, and the experimental group was treated with radiofrequency. The improvement effect, skin elasticity parameter level, adverse reactions and treatment satisfaction were compared between the two groups. Results After treatment, the degree of facial lifting, nasolabial groove lifting and eyebrow lifting in the experimental group were better than those in the control group (P<0.05). After treatment, the skin elasticity parameters R2, R5 and R7 in the experimental group were better than those in the control group (P<0.05). The incidence of adverse reactions in the experimental group was 2.86%, which was lower than 17.14% in the control group (P<0.05). The treatment satisfaction of the experimental group was 97.14%, which was higher than 80.00% of the control group (P<0.05). Conclusion The application effect of radiofrequency technology in the treatment of facial rejuvenation is accurate, and its efficacy is better than that of water and light injection therapy, which can effectively improve the face, nasolabial groove and eyebrow of patients, improve the skin texture, and with less adverse reactions and higher safety. It has been satisfied and recognized by patients.