The plastic and cosmetic industry has developed rapidly, and the scale of medical device industry is also gradually expanding. However, China's current medical device clinical research management program still needs to be further improved, some research institutions management concept is weak, resulting in some fake commodities into the market. This paper mainly summarizes the current situation and existing problems of clinical trials of plastic and cosmetic medical devices, and puts forward the management strategies of clinical research and clinical trials of medical devices, in order to improve the risk awareness of medical device clinical researchers, and improve and perfect the risk management of plastic and cosmetic medical device clinical trials.