Objective To investigate the effect of acid combined with intense pulsed light on chloasma and its effect on oxidative stress in patients. Methods A total of 62 patients with chloasma admitted to the Department of Cosmetology of our hospital from January 2020 to December 2021 were selected and divided into control group and observation group according to random number table method, with 31 cases in each group. The control group was treated with intense pulsed light, and the observation group was treated with fruit acid on the basis of the control group. The therapeutic effect, oxidative stress indexes [malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px)], skin moisture and lesion evaluation scores, skin characteristics (pigment spots, pores, purple, wrinkles and textures) related scores and adverse reactions were compared between the two groups. Results The total effective rate of the observation group was 93.55%, which was higher than 70.97% of the control group, the difference was statistically significant (P<0.05). MDA level in the observation group was lower than that in the control group, and SOD and GSP-Px levels were higher than those in the control group, the difference was statistically significant (P<0.05). The water loss and skin lesion score of the observation group were lower than those of the control group, and the water content of the skin stratum corneum was higher than that of the control group, the difference was statistically significant (P<0.05). The scores of pigment spots, pores, purple, wrinkles and texture in the observation group were lower than those in the control group, the difference was statistically significant (P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05). Conclusion Fruit acid combined with intense pulsed light is effective in the treatment of chloasma, which can inhibit oxidative stress reaction, improve skin injury, and has less adverse reactions.