他克莫司软膏联合二氧化碳点阵激光治疗白癜风的效果观察
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李自华(1979.11-),男,陕西商洛人,本科,主治医师,主要从事皮肤性病诊治及激光美容治疗工作

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R758.41

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Effect of Tacrolimus Ointment Combined with Carbon Dioxide Fractional Laser on Vitiligo
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    摘要:

    目的 探讨白癜风临床治疗期间采用他克莫司软膏结合二氧化碳点阵激光进行治疗的效果优势方法 选取2019年1月-2021年3月镇安县医院治疗白癜风患者80例,根据随机数字表法分为常规组和实验组,各40例。常规组应用他克莫司软膏进行治疗,实验组在常规组治疗基础上结合应用二氧化碳点阵激光,比较两组治疗有效率、血清炎性因子水平(肿瘤坏死因子-α、γ干扰素、白细胞介素-17)和不良反应结果 实验组总有效率为97.50%,高于常规组的80.00%(P<0.05);治疗6个月后实验组肿瘤坏死因子-α、γ干扰素、白细胞介素-17均低于常规组(P<0.05);实验组不良反应总发生率为5.00%,低于常规组的25.50%(P<0.05)结论 他克莫司软膏结合二氧化碳点阵激光的治疗效果显著,对于白癜风症状的控制作用显著,有着较为理想的干预作用。

    Abstract:

    Objective To investigate the advantages of tacrolimus ointment combined with carbon dioxide fractional laser in the treatment of vitiligo. Methods A total of 80 patients with vitiligo in Zhen'an County Hospital from January 2019 to March 2021 were randomly divided into routine group and experimental group, with 40 cases in each group. The conventional group was treated with tacrolimus ointment, and the experimental group was treated with carbon dioxide lattice laser on the basis of the conventional group. The effective rate, serum inflammatory factor levels (tumor necrosis factor-α, interferon-γ, interleukin-17) and adverse reactions were compared between the two groups. Results The total effective rate of the experimental group was 97.50%, which was higher than 80.00% of the conventional group (P<0.05). After 6 months of treatment, tumor necrosis factor-α, interferon-γ and interleukin-17 in the experimental group were lower than those in the conventional group (P<0.05). The tatal incidence of adverse reactions in the experimental group was 5.00%, which was lower than 25.50% in the conventional group (P<0.05). Conclusion Tacrolimus ointment combined with carbon dioxide dot matrix laser has obvious therapeutic effect, and has an ideal intervention effect on vitiligo.

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李自华,周婕.他克莫司软膏联合二氧化碳点阵激光治疗白癜风的效果观察[J].医学美学美容,2022,31(1):24-26.

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  • 在线发布日期: 2022-08-06
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