左玉辉(1969.1-),女,河南郸城人,硕士,副主任医师,主要从事皮肤和皮肤美容工作
R738.63
目的 评估他扎罗汀他米松乳膏在慢性斑块型银屑病中的临床效果方法 选取2020年 1月-2021年8月在我院诊治的62例慢性斑块型银屑病患者，随机分为观察组和对照组，每组31例。观察组外用他扎罗汀倍他米松乳膏，对照组外用卡泊三醇软膏。比较两组医生对病情的总体评估(PGA)、银屑病皮损面积和严重程度指数(PASI)、症状评分、皮肤病生活质量指数(DLQI)、炎性因子指标、用药安全性以及临床治疗效果结果 观察组PGA、PASI、症状评分、DLQI、炎性因子指标均低于对照组(P ＜0.05)；两组不良反应发生率比较，差异无统计学意义(P＞0.05)；观察组治疗总有效率(67.74%) 高于对照组(38.71%)(P＜0.05)结论 慢性斑块型银屑病患者外用他扎罗汀倍他米松乳膏的不良反应少，能够降低炎性因子表达水平，快速缓解症状，提高患者的生活质量，改善临床治疗效果。
Objective To evaluate the clinical effect of tazarotene and betamethasone dipropionate cream in the treatment of chronic plaque psoriasis. Methods A total of 62 patients with chronic plaque psoriasis treated in our hospital from January 2020 to August 2021 were selected and randomly divided into observation group and control group, with 31 cases in each group. The observation group was treated with tazarotene and betamethasone dipropionate cream and the control group was treated with calcipotriol ointment. The overall assessment (PGA), psoriasis lesion area and severity index (PASI), symptom score, skin disease quality of life index (DLQI) and medication safety of the two groups were compared. Results The PGA, PASI, symptom score, DLQI and inflammatory factors in the observation group were lower than those in the control group (P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion Tazarotene and betamethasone dipropionate cream has less adverse reactions in patients with chronic plaque psoriasis, which can reduce the expression of inflammatory factors, quickly relieve symptoms and improve the quality of life of patients.
左玉辉,谭芬芳,覃萍,等.他扎罗汀倍他米松乳膏治疗慢性斑块型银屑病的临床效果[J].医学美学美容,2022,31(1):5-8.
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